Four year old Male castrated Shiba Inu with a history of acute onset of lameness with no history of trauma. Patient was non-weightbearing at exam. Radiographs revealed a lytic and proliferative bone lesions at the head and neck of the left femur. Ultrasound guided aspirates were taken through the cortex down to the compromised subcortical region using a 20-g catheter needle. Aspirates taken from bone lesion via ultrasound guidance Cytologic diagnosis consistent with Osteosarcoma Slide 1 Slide 1 (current slide) Slide 2 Slide 2 (current slide) Slide 3 Slide 3 (current slide) Slide 4 Slide 4 (current slide) Slide 5 Slide 5 (current slide)